Protein Details: 5-hydroxytryptamine receptor 3E

Protein ID

ICDB_Pro_0055

Protein Name

5-hydroxytryptamine receptor 3E

Gene Name

HTR3E

Organism

Homo sapiens (Human)

Length

456 amino acids

AlphaFoldDB

AF-A5X5Y0-F1-model_v4.pdb

Function

Forms serotonin (5-hydroxytryptamine/5-HT3)-activated cation-selective channel complexes;which when activated cause fast;depolarizing responses in neurons.

Sequence

MEGSWFHRKRFSFYLLLGFLLQGRGVTFTINCSGFGQHGADPTALNSVFNRKPFRPVTNISVPTQVNISFAMSAILDVNEQLHLLSSFLWLEMVWDNPFISWNPEECEGITKMSMAAKNLWLPDIFIIELMDVDKTPKGLTAYVSNEGRIRYKKPMKVDSICNLDIFYFPFDQQNCTLTFSSFLYTVDSMLLDMEKEVWEITDASRNILQTHGEWELLGLSKATAKLSRGGNLYDQIVFYVAIRRRPSLYVINLLVPSGFLVAIDALSFYLPVKSGNRVPFKITLLLGYNVFLLMMSDLLPTSGTPLIGVYFALCLSLMVGSLLETIFITHLLHVATTQPPPLPRWLHSLLLHCNSPGRCCPTAPQKENKGPGLTPTHLPGVKEPEVSAGQMPGPAEAELTGGSEWTRAQREHEAQKQHSVELWLQFSHAMDAMLFRLYLLFMASSIITVICLWNT

PDB Structures

Ligand Binding

1. DICL_CP

2. DICL_Pep

Binding Site

Disease

Ischemic Colitis and Currarino Syndrome

Location

Expressed in adult colon and intestine

DOI ID

10.1016/s0378-1119(03)00503-1; 10.1016/s0378-1119(03)00803-5; 10.1124/mol.106.032144; 10.1111/j.1471-4159.2008.05775.x; 10.1038/nature04728; 10.1101/gr.2596504

RefSeq

NP_001243542.1 [A5X5Y0-1]; NP_001243543.1 [A5X5Y0-6]; NP_872395.2 [A5X5Y0-3]; NP_938055.1 [A5X5Y0-2]; NP_938056.1 [A5X5Y0-4]